High-resolution mass spectrometry (HRMS) is a mass spectrometry technique for trace level molecular analysis in vaporized samples. It achieves accurate mass measurement (~0.001 Da) and identification of isotopes. Infinita Lab, USA, offers this test to clients in the USA and across the world through its vast laboratory network. ... Read More
Average 30% Cost Savings
100% Confidentiality Guarantee
Free, No-obligation Consultation
100% Customer Satisfaction
TRUSTED BY ENGINEERS FROM
High-Resolution Mass Spectrometry (HRMS)
High-resolution mass spectrometry (HRMS) is a mass spectrometry technique for trace level analysis. HRMS can achieve mass measurement accuracy of 0.001 Da and detect trace quantities (mDa) of elements. The underlying mass spectrometry principle involves ionization of analyte compounds in vapour phase, accelerating the ionized fragments in an electric field and separating them by mass analyzer, based on the mass to charge ratios (m/z). The separated ions are detected using electron multiplier detectors. The intensities of the detected ions, when plotted against mass to charge ratios, constitute the characteristic mass spectra. Enhanced mass resolution of HRMS enables identification of isotopes and compounds with similar ‘m/z’ ratios, that overlap on mass spectra at lower resolutions. Various methods for ionization such as electron ionization, chemical ionization and cold electron ionization are used, depending on the application. HRMS uses conventional mass analyzers including magnetic sector, quadrupole, ion-trap or time-of-flight (TOF) analyzers in tandem or hybrid mode, augmented by other techniques to achieve high resolution based on analytical need and economics. For example, a resolution of 50,000 can distinguish ions differing by about 50 ppm, which can be accomplished by a High-Resolution-TOF mass analyzer. On the other hand, FT-ICR-MS (Fourier transform ion cyclotron resonance mass spectrometry) can provide resolution of 1000,000 but would be more expensive. HRMS finds application in bioanalytical research, drug screening, doping control, glycomics and proteomics, food analysis, environmental sciences, clinical toxicology and forensics.
Common Uses of High-Resolution Mass Spectrometry (HRMS)
Biomolecule analysis
Environment analysis
Pesticide residue analysis
Forensic analysis
Drugs and metabolites analysis
Medical research
Food industry
Advantages of High-Resolution Mass Spectrometry (HRMS)
Accurate mass measurements
Ability to identify isotopes
Wide range of high-resolution powers depending on analyzer configuration
Limitations of High-Resolution Mass Spectrometry (HRMS)
Higher resolution instrumentation is expensive, so trade-off is required
Industrial Applications of High-Resolution Mass Spectrometry (HRMS)
Pharmaceutical
Food and beverages
Agrochemicals
Environment
Medical research
Drug abuse/ Doping control
Forensics
Featured Metrology Testing Services
Select Other Metrology Testing Services From Catalogue
Mass Spectrometry (MS) gives the nominal mass of a specimen, whereas High-Resolution Mass Spectrometry (HRMS) gives the exact mass. HRMS provides highly precise mass values with an accuracy of many decimal places. In comparison, MS cannot distinguish between two complexes which have a very small difference in mass.
The different types of High-Resolution Mass Spectrometry (HRMS) include:
1. Time-Of-Flight MS (TOFMS)
2. Orbitrap MS
3. Fourier Transform Ion Cyclotron Resonance (FT-ICR) MS
High-Resolution Mass Spectrometry (HRMS) is a mass spectrometry technique used for trace level molecular analysis in vaporized samples. HRMS can achieve mass measurement accuracy of 0.001 Da and detect trace quantities (mDa) of elements.
The underlying mass spectrometry principle involves ionization of analyte compounds in vapour phase, accelerating the ionized fragments in an electric field and separating them by mass analyzer, based on the mass to charge ratios (m/z).
ASTM E572 test method covers the analysis of stainless and alloy steels by Wavelength Dispersive X-ray Fluorescence Spectrometry (WDXRF). It provides rapid, multi-element determinations with sufficient accuracy to assure product quality.
The ASTM D2674 test is a standard test method for the analysis of sulfochromate etch solutions used in the surface preparation of aluminum. The ASTM D2674 standard specifies a method for determining the efficacy of an etchant used to prepare the surface of aluminum alloys for subsequent adhesive bonding.
An immunological method for quantization of Hevea Natural Rubber (HNRL) proteins using rabbit anti-HNRL serum. Rabbits immunized with HNRL proteins react to the majority of the proteins present, and their sera have the capability to detect most if not all the proteins in HNRL.
ASTM G65 measures the resistance of metallic materials to abrasion using the dry sand/rubber wheel apparatus. The quality, durability, and toughness of the sample are determined using this test. Metallic materials are ranked in their resistance to scratching abrasion under a controlled environment.
ASTM E2141 test methods provide accelerated aging and monitoring of the performance of time-dependent electrochromic devices (ECD) integrated in insulating glass units (IGU). This test helps to understand the relative serviceability of electrochromic glazings applied on ECD.
ASTM C724 test method is used in analyzing the quality and ease of maintenance of a ceramic decoration on architectural-type glass. This test method is useful in the acknowledgment of technical standards.
Send us a request
Process for testing
STEP 01
You share material and testing requirements with us
STEP 02
You ship your sample to us or arrange for us to pick it up.
STEP 03
We deliver the test report to your email.
Just share your testing requirements and leave the rest on us!
Free, no-obligation consultation
Guaranteed confidentiality
Quick turnaround time
Hassle-free process
Let us combine our capabilities to achieve success!!
