Liquid Chromatography-Mass Spectroscopy (LC-MS) is an analytical technique used for the separation, identification, and quantification of the chemical constituents of a sample. Testing labs under the Infinita Lab network provide the best LC-MS analysis for our clients based in the USA and other countries.... Read More
Liquid Chromatography-Mass Spectroscopy (LC-MS) is an analytical technique that allows the separation, identification, and quantification of the sample constituents. It is the preferred separation technique for larger and non-volatile molecules like proteins and peptides. It’s also ideal for the separation of isomers (same mass) which cannot be differentiated in a mass spectrometer. With its high sensitivity, high detection selectivity, and multicomponent analysis capabilities, LC-MS is used for qualitative and quantitative analysis of trace elements, contaminants, additives, etc. in a wide range of industries from drug delivery, clinical research, biopharmaceuticals to textiles and environmental sciences.
In LC, a sample is injected and adsorbed on the stationary phase (porous medium) as the liquid mobile phase passes through the column to separate the compounds. Compounds are separated based on their weight and affinity towards the stationary and mobile phases. The separated analytes then pass through a mass detector that differentiates compounds by their mass-to-charge ratio (m/z). MS provides information about the identity, quantity, molecular weight, and purity of a sample.
We at Infinita Lab are committed to providing the best routine and advanced Liquid Chromatography-Mass Spectroscopy analyses for our clients based in the USA and across the world. Our testing laboratory has various state-of-the-art instruments and methodologies to perform LC-MS experiments.
Liquid Chromatography-Mass Spectroscopy (LC-MS) Common Uses
Advantages of Liquid Chromatography-Mass Spectroscopy (LC-MS)
Limitations of Liquid Chromatography-Mass Spectroscopy (LC-MS)
Industries where Liquid Chromatography-Mass Spectroscopy (LC-MS) is used
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You can get your materials analyzed right here at Infinita Lab. Our network of material testing labs provides identification, quantitation, and mass analysis of materials using liquid chromatography-mass spectrometry (LC-MS).
Trace element analysis and chemical purity analysis using liquid chromatography-mass spectrometry (LC-MS) starts from $450/sample
Liquid chromatography-mass spectrometry (LC-MS) is used for quantitative and qualitative analysis of materials. It can detect trace levels of polymer extractables and leachables, plasticizers, surfactants, pharmaceuticals, etc. Higher sensitivity and specificity in detection can be achieved with the use of quadrupole spectrometers in LC-MS analysis.
Both techniques work on the same principle. However, during the separation process, gas chromatography-mass spectrometry (GC-MS) uses gaseous phase eluent to separate analytes, whereas liquid chromatography-mass spectrometry (LC-MS) uses a liquid solvent. Although LC-MS cannot handle gaseous or volatile samples, it can analyze thermally unstable samples like biological fluids.
ASTM E572 test method covers the analysis of stainless and alloy steels by Wavelength Dispersive X-ray Fluorescence Spectrometry (WDXRF). It provides rapid, multi-element determinations with sufficient accuracy to assure product quality.
The ASTM D2674 test is a standard test method for the analysis of sulfochromate etch solutions used in the surface preparation of aluminum. The ASTM D2674 standard specifies a method for determining the efficacy of an etchant used to prepare the surface of aluminum alloys for subsequent adhesive bonding.
An immunological method for quantization of Hevea Natural Rubber (HNRL) proteins using rabbit anti-HNRL serum. Rabbits immunized with HNRL proteins react to the majority of the proteins present, and their sera have the capability to detect most if not all the proteins in HNRL.
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ASTM E2141 test methods provide accelerated aging and monitoring of the performance of time-dependent electrochromic devices (ECD) integrated in insulating glass units (IGU). This test helps to understand the relative serviceability of electrochromic glazings applied on ECD.
ASTM C724 test method is used in analyzing the quality and ease of maintenance of a ceramic decoration on architectural-type glass. This test method is useful in the acknowledgment of technical standards.
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