Gas Chromatography Mass Spectroscopy – GCMS

GCMS is a chemical analysis technique widely used in GCMS testing labs to identify chemical components, contaminants, and trace elements within a specimen. It combines two powerful techniques, Gas chromatography and Mass Spectroscopy, to separate and analyze constituents of volatile compounds. ... Read More

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    Gas Chromatography-Mass Spectrometry (GCMS) Analysis Services

    GCMS is a chemical analysis technique widely used to identify chemical components, contaminants, and trace elements within a specimen. It combines two powerful techniques to separate and analyze constituents of, typically, volatile compounds. In the Gas Chromatography (GC) process, the sample is vaporized and carried over a packed capillary column, where they are separated. Sample constituents are identified by comparing them against reference standards. The components leaving GC are ionized and fragmented as they enter the Mass Spectrometer (MS). A mass analyzer (e.g., a quadrupole detector) separates and analyzes the ionized molecules based on their mass to charge ratio (m/z). Peaks appear as a function of m/z, and these reproducible mass spectra are used to identify the molecules and perform quantitative analysis.

    Running GC tandem with multiple, variant MS detector units adds additional fragmentation steps for the sample components. Tandem MS is beneficial for identifying and analyzing targeted molecules, where low detection limits are required. Examples of such variants include GC-MS/MS or GC/MS-TOF (Time of Flight). Options like Selected Ion Monitoring (SIM) in MS are also available for quantitative analysis of trace components in a laboratory.

    Infinita Lab is committed to providing the best testing labs facility to our clients based in the USA and across the world. All the tests are done in the best-equipped testing laboratory for utmost client satisfaction.

    Common Uses of Gas Chromatography-Mass Spectroscopy Technique

    • Identification and quantification of unknown samples
    • Quantification of contaminants in food testing and toxicology
    • Product quality testing and quality control
    • Trace element analysis
    • Chemical outgassing studies
    • Development of new testing standards

    GCMS Advantages:

    • Low detection limits (~pico grams)
    • Broad m/z range up to 1050
    • High efficiency and multi-stage separation of components
    • Higher specificity and reproducibility compared to LC-MS
    • Tiny sample required: µL for gasses and liquids and 0.5-1g for solids


    • Solid and liquid samples need to be able to degas for analysis
    • Slow analysis time
    • Additional sample preparation steps required for non-volatile samples

     Industries using GCMS tests:

    • Semiconductors
    • Food and Beverage Industry
    • Chemicals
    • Plastics and Packaging
    • Pharmaceuticals
    • Drug Testing
    • Environmental Science
    • Clinical and biological testing
    • Cosmetics
    • Compliance and Regulatory Testing
    • Forensic Science
    • Geology
    • Oil and Gas

    More Details:

    Fundamentals of GC-MS and its applications
    GC-MS Instrumentation
    GC-MS Variants and their applications
    GC-MS in regulatory compliance

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      FAQs on Gas Chromatography Mass Spectroscopy – GCMS

      Where can I get Gas Chromatography-Mass Spectroscopy (GC-MS) analysis done?

      Our network of material testing labs, spread across the USA, provides GC-MS testing services to identify different substances in a sample. Infinita Lab team will be happy to assist you with your GC-MS analysis requirements. 


      How much does GC-MS analysis cost?

      GC-MS analysis covers a wide range of tests. The cost of a test depends on the type of the test. Thermal desorption study of materials with gas chromatography-mass spectrometry (GC-MS) starts from $390.

      What is gas chromatography-mass spectrometry (GC-MS) used for?

      Gas chromatography-mass spectrometry (GC-MS) combines the features of gas-chromatography and mass spectrometry to identify different substances within a sample. GC-MS is used in drug detection, fire investigation, explosives investigation, and identification of unknown samples. 

      What is the difference between GC-MS and LC-MS?

      Both GC-MS and LC-MS work on the same principle. However, during the separation process, the gas chromatography-mass spectrometry (GC-MS) technique uses a gas phase to separate analytes, whereas liquid chromatography-mass spectrometry (LC-MS) uses a liquid solvent. 

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