ASTM D7709 Measuring Water Vapor Transmission Rate of Pharmaceutical Bottles

Scope:

The goal of the ASTM D7709 tests is to acquire accurate WVTR results that can be utilized to distinguish between different barrier packages for medicinal goods.

Procedure:

ASTM D7709 desiccant is poured into the bottle, which is then closed in the usual manner, including any membrane (tamper-evident or otherwise) sealed in place. The desiccant-filled bottle is kept at 40°C and has 75% relative humidity. The desiccant-filled container is weighed at regular intervals until it reaches a steady-state weight growth. Once the bottles have reached a steady-state, they are weighed five times in a row.

Video 01: Method to calculate WVTR of HDPE bottles

Specimen size:

Specimens used in ASTM D7709 testing should be conditioned at 40 ± 2°C and 75 ± 5 percent RH.

Data:

The following formula is used in ASTM D7709 testing:

slope (M) =^NƩ_i=1 [(W_i  ̶   W) (T_i ̶  T)]/ ^NƩ_i=1 (T_i ̶  T)²

W_i= measured weight

W= overall weight average

T_i= time point

T= Average time

Conclusion:

The goal of the ASTM D7709 tests is to acquire accurate WVTR results that can be utilized to distinguish between different barrier packages for medicinal goods.