ASTM D7709 Measuring Water Vapor Transmission Rate of Pharmaceutical Bottles

ASTM D7709 Measuring Water Vapor Transmission Rate of Pharmaceutical Bottles

ASTM D7709 is used to measure the water vapor transmission rates (WVTRs) of high-barrier multiple-unit containers (bottles), high-barrier single-unit containers (blisters), and quasi-barrier single-unit containers used for packaging pharmaceutical items. The values stated in SI are considered standard.


    The goal of these tests is to acquire accurate WVTR results that can be utilized to distinguish between different barrier packages for medicinal goods.


    ASTM D7709 desiccant is poured into the bottle, which is then closed in the usual manner, including any membrane (tamper-evident or otherwise) sealed in place. The desiccant-filled bottle is kept at 40°C and has 75% relative humidity. The desiccant-filled container is weighed at regular intervals until it reaches steady-state weight growth. Once the bottles have reached a steady-state, they are weighed five times in a row.

    Specimen size:

    Specimens should be conditioned at 40 ± 2°C and 75 ± 5 percent RH.


    slope (M) =NƩi=1 [(Wi  ̶   W) (Ti ̶  T)]/ NƩi=1 (Ti ̶  T)2

    W= measured weight

    W= overall weight average

    T= time point

    T= Average time


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