ASTM D7709 Measuring Water Vapor Transmission Rate of Pharmaceutical Bottles

ASTM D7709 is used to measure the water vapor transmission rates (WVTRs) of high-barrier multiple-unit containers (bottl es), high-barrier single-unit containers (blisters), and quasi-barrier single-unit containers used for packaging pharmaceutical items. The values stated in SI are considered standard.... Read More

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    Scope:

    The goal of the ASTM D7709 tests is to acquire accurate WVTR results that can be utilized to distinguish between different barrier packages for medicinal goods.

    Procedure:

    ASTM D7709 desiccant is poured into the bottle, which is then closed in the usual manner, including any membrane (tamper-evident or otherwise) sealed in place. The desiccant-filled bottle is kept at 40°C and has 75% relative humidity. The desiccant-filled container is weighed at regular intervals until it reaches a steady-state weight growth. Once the bottles have reached a steady-state, they are weighed five times in a row.

    Video 01: Method to calculate WVTR of HDPE bottles

    Specimen size:

    Specimens used in ASTM D7709 testing should be conditioned at 40 ± 2°C and 75 ± 5 percent RH.

    Data:

    The following formula is used in ASTM D7709 testing:

    slope (M) =NƩi=1 [(Wi  ̶   W) (Ti ̶  T)]/ NƩi=1 (Ti ̶  T)2

    Wi= measured weight

    W= overall weight average

    Ti= time point

    T= Average time

    Conclusion:

    The goal of the ASTM D7709 tests is to acquire accurate WVTR results that can be utilized to distinguish between different barrier packages for medicinal goods.

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