Systemic Toxicity Test
Aerospace corrosion testing per MIL-STD-810 evaluating alloy and coating protection performanceSystemic Toxicity Test
Systemic toxicology is the study of the effects of chemical substances and medical devices on the body. Acute Systemic Injection Tests (ASIT) are conducted to assess the potential risks of acute exposure to a chemical substance or medical device. During the test, animals are given an injection of the test article extract intravenously or intraperitoneally, followed by monitoring of the animals’ health at 24, 48, and 72 hours intervals.
The Material Mediated Pyrogen Test (MMPT) is a method used to evaluate the potential of a chemical agent or material to cause a pyrogenic response. After the animals receive an intravenous injection of the test article extract, they are monitored for three hours in search of a temperature change of less than 0.5 degrees Celsius.
These tests are essential for any medical device that comes into contact with the human body and must comply with the requirements set out by ISO 10993-11 and ISO 10993-12. Systemic toxicology is a vital component of medical device testing to ensure patient safety.
Video 01: Toxicology
